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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Cell Metab. 2019 Aug 22;30(3):556–572.e5. doi: 10.1016/j.cmet.2019.07.012

Figure 2.

Figure 2.

Upregulation of lipid metabolic genes by MYC. (A) Diagram of MYC’s regulation of the fatty acid synthesis pathway. (B) qPCR shows fatty acid synthesis mRNA expression in high MYC (MYC ON, N=3 per cell line) compared to 24 hours of MYC inactivation (MYC OFF, N=3 per cell line) in BCL (P493–6) and RCC (E28). Expression of lipogenesis proteins for BCL (P493–6) and RCC (E28) cells with MYC ON vs. MYC OFF, by Western blot analysis. Statistical significance by t-test, ***P<0.001. (C) RNA-seq analysis of lipid metabolic pathways in fold-change of RPKM comparing MYC ON/MYC OFF in BCL (P493–6).