Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Apr 20;131:82–90. doi: 10.1016/j.yjmcc.2019.04.015

Fig. 3.

Fig. 3.

Blockade of JNK activation improves serotonin-induced dilation of coronary arterioles isolated from diabetic pigs. Dilation of isolated and pressurized porcine coronary arterioles to serotonin was examined after 2 weeks of euglycemia (Control; n = 8) or hyperglycemia (Diabetes; n = 9). In another cohort of diabetic vessels, vasodilation to serotonin was examined in the presence of JNK inhibitors SP600125 (n = 6) or BI-78D3 (n = 3), or p38 kinase inhibitor SB203580 (n = 6). *P<0.05 vs. Control, #P<0.05 vs. Diabetes, two-way ANOVA with Bonferroni multiple-range test.