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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Eur Neuropsychopharmacol. 2019 Oct 1;29(11):1288–1294. doi: 10.1016/j.euroneuro.2019.09.004

Figure 2.

Figure 2.

Recordings in layer V pyramidal neurons (IL cortex) of aCSF, GLAST and GLT-1 siRNA treated mice show significant changes in synaptic properties. (a) Representative traces of spontaneous (sEPSC) and miniature (mEPSC) EPSCs in mice of each group. (b) sEPSCs analysis revealed an increase in both amplitude and frequency in mice with reduced expression of glutamate transporters compared to control mice. (c) Bar graph showing no changes in mEPSC amplitude, but a lower frequency in siRNA-treated mice. (d) Representative trace showing the difference between a SIC and an EPSC shape in the different experimental groups. Analysis of SICs revealed a significant increase in both amplitude and frequency, as well as longer SIC time courses (a higher 10–90% rise and decay time of GLAST and GLT-1 knockdown mice compared to controls. Data are presented as the mean±SEM. P<0.05 (*), P<0.01 (**), and P<0.001 (***).