Figure 4.

Determining ADCC with IL-15/IL-15Rα in an orthotopic PDX mouse model. A, Nude mice aged 5 to 6 weeks were injected orthotopically with the PDX SJNBL046_X in the para-adrenal space. Four to 5 weeks after injection, mice with tumor volumes measuring ≥ 10 mm³ by ultrasound were randomly assigned to four therapy groups. B, Therapy schema. Animals received two courses of therapy, each lasting 3 weeks. C, Median tumor growth over time in all four therapy groups. D, Waterfall plots showing the relative tumor volume change at the end of therapy compared to baseline measurements for individual mice in each therapy group.