Figure 2:

Calcification in human IAs (A) occupies less than 0.1% of sample wall volume, (B) exists mostly as small (< 30μm) micro-calcifications which can exist in clusters and (C, D) does not associate with any specific tissue surface color even when it occupies a large volume.(E) Calcification area fraction increases with increasing distance from lumen (p = 0.016; n = 50). (F) Calcification in the outer third of the wall is found in regions of high relative wall thickness - the ratio of thickness in the calcified region relative to average wall thickness for that specimen (p = 0.0001,0.0001; n = 50) whereas calcification in the inner and middle layer occurs in region of average wall thickness. A relative wall thickness of 1 indicates the calcified wall region has a thickness equal to the average wall thickness of the particular specimen.