Table 1.
Anthropometry and Biochemical Characteristics of the Study Subjects before and after Nasal Continuous Positive Airway Pressure Therapy.
| before | after | p | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean±SD/Median (minimum-maximum) |
N | Mean±SD/Median (minimum-maximum) |
||||||
| age (year) | 76 | 62.0 (25-88) | |||||||
| gender (M/F) | 76 | 63/13 | |||||||
| body weight (kg) | 62 | 74.5±16.1 | |||||||
| BMI (kg/m2) | 62 | 25.8 (16.9-44.7) | |||||||
| waist circumference (cm) | 62 | 94.9±12.2 | |||||||
| fat mass (kg) | 62 | 19.0 (7.5-47.6) | |||||||
| fat-free mass (kg) | 62 | 52.6 (5.5-73.1) | |||||||
| nCPAP therapy period (day) | 62 | 123 (10-1,662) | |||||||
| nCPAP mounting time (hours/day) | 75 | 4.8±1.9 | |||||||
| Epworth sleepiness scale test (point) | 76 | 7 (0-24) | |||||||
| apnea index (events/hour) | 75 | 18.9 (0.0-138.7) | 67 | 0.3 (0.0-8.7) | <0.001 | ||||
| hypopnea index (events/hour) | 75 | 17.6 (0.0-76.7) | 67 | 2.3 (0.2-23.1) | <0.001 | ||||
| apnea-hypopnea index (events/hour) | 75 | 45.0 (6.8-141.4) | 76 | 2.6 (0.3-23.1) | <0.001 | ||||
| 3% oxygen desaturation index (events/hour) | 73 | 30.9 (4.3-97.6) | 66 | 1.0 (0.0-17.2) | <0.001 | ||||
| % SpO2<90% (% of total sleep time) | 74 | 7.29 (0.00-76.91) | 67 | 0.00 (0.00-14.0) | <0.001 | ||||
| SpO2 minimum (%) | 75 | 76 (38-90) | 67 | 90 (73-97) | <0.001 | ||||
| arousal index (events/hour) | 74 | 39.7 (12.5-120.2) | 64 | 16.8 (0.0-52.3) | <0.001 | ||||
| burst rate (bursts/minute) | 58 | 62 (24-101) | 38 | 44 (23-74) | <0.001 | ||||
| burst incidence (bursts/100 heartbeats) | 58 | 88 (42-100) | 38 | 58 (42-100) | <0.001 | ||||
| systolic blood pressure (mmHg) | 73 | 131 (98-165) | 63 | 130 (107-174) | 0.645 | ||||
| diastolic blood pressure (mmHg) | 73 | 80 (39-117) | 63 | 76 (56-109) | 0.071 | ||||
| heart rate (beats/minute) | 58 | 71±11 | 38 | 69±11 | 0.017 | ||||
| fasting plasma glucose (mg/dL) | 63 | 94 (79-159) | 20 | 94 (86-150) | 0.663 | ||||
| HbA1c (%) | 76 | 5.9 (4.6-9.4) | 19 | 6.0 (5.2-8.8) | 0.360 | ||||
| HOMA-beta | 57 | 55 (6-241) | 20 | 67 (7-285) | 0.296 | ||||
| insulinogenic index | 58 | 0.4 (0.0-1.9) | 20 | 0.3 (-0.6-1.8) | 0.224 | ||||
| HOMA-IR | 57 | 1.2 (0.1-3.9) | 20 | 1.5 (0.6-5.9) | 0.931 | ||||
| QUICKI | 57 | 0.37 (0.31-0.61) | 20 | 0.36 (0.30-0.42) | 0.849 | ||||
| Matsuda index | 56 | 7.1 (1.3-89.0) | 20 | 8.8 (1.2-21.7) | 0.058 | ||||
| hepatic insulin resistance index | 56 | 2.2×106 (2.5×104-1.3×107) | 20 | 1.6×106 (1.0×105-1.2×107) | 0.157 | ||||
nCPAP: nasal continuous positive airway pressure, HOMA-beta: homeostatic model assessment beta cell function, HOMA-IR: homeostasis model assessment of insulin resistance, QUICKI: quantitative insulin sensitivity check index