Table 3.
Characteristics | N | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|---|
3-year OS | p | HR (95% CI) | p | ||
Age | |||||
<65 | 1055 | 84.6% | 0.014 | 1 | |
≥65 | 139 | 75.1% | 1.7 (1.1–2.7) | 0.011 | |
Histology | |||||
SCC | 1065 | 84.9% | <0.001 | 1 | |
Non-SCC | 129 | 71.5% | 2.3 (1.6–3.5) | <0.001 | |
Tumor size | |||||
<4cm | 477 | 90.3% | <0.001 | 1 | |
≥4cm | 717 | 79.0% | 1.7 (1.2–2.5) | 0.004 | |
FIGO stage | |||||
I | 154 | 90.8% | <0.001 | 1 | |
II | 826 | 85.3% | 1.6 (0.8–3.1) | 0.144 | |
III | 205 | 72.7% | 2.8 (1.4–5.7) | 0.003 | |
IVA | 9 | 21.4% | 1.8 (0.5–6.9) | 0.362 | |
Mesorectum MLNs | |||||
Yes | 1184 | 0% | <0.001 | 4.0 (1.8–9.1) | 0.001 |
No | 10 | 84.4% | 1 | ||
Para-aortic MLNs | |||||
Yes | 81 | 44.0% | <0.001 | 1.8 (1.1–2.8) | 0.017 |
No | 1113 | 86.3% | 1 | ||
Pelvic MLNs | |||||
Yes | 353 | 69.3% | <0.001 | 2.5 (1.7–3.7) | <0.001 |
No | 841 | 89.2% | 1 | ||
Common iliac MLNs | |||||
Yes | 96 | 52.0% | <0.001 | 1.5 (0.95–2.3) | 0.082 |
No | 1098 | 86.1% | 1 | ||
Bilateral pelvic MLNs | |||||
Yes | 209 | 63.5% | <0.001 | 1.0 (0.7–1.6) | 0.938 |
No | 985 | 87.6% | 1 | ||
Treatment approach | |||||
RT | 177 | 74.4% | 0.001 | 1 | |
CCRT | 1017 | 85.0% | 0.6 (0.4–0.9) | 0.010 |
Abbreviations: MLNs, metastatic lymph nodes; SCC, squamous cell carcinoma.