Table 2: Results.
Data are reported as unadjusted means±SD.
| Colchicine | Placebo | p value for: | |||||
|---|---|---|---|---|---|---|---|
| Variable | Pre (n=18) | Post (n=18) | Pre (n=19) | Post (n=19) | Time | Group | Time*Group Interaction |
| Inflammatory | |||||||
| hsCRP (mg/L) | 7.5±7.8 | 3.0±1.9 | 6.7±4.2 | 8.7±8.1 | 0.23 | 0.027 | 0.0001 |
| ESR (mm/h) | 17.4±12.1 | 10.9±7.4 | 21.0±12.8 | 21.6±12.0 | 0.93 | 0.10 | 0.004 |
| GlycA (μmol/L) | 424.5±62.3 | 393.1±60.5 | 422.1±39.7 | 438.3±37.5 | 0.63 | 0.32 | 0.0007 |
| Insulin Resistance | |||||||
| Lipoprotein Insulin Resistance Index | 59.7±23.8 | 59.5±16.2 | 60.4±21.2 | 62.7±22.3 | 0.82 | 0.76 | 0.69 |
| Lipoprotein Parameters | |||||||
| VLDL Particles (nmol/L) | |||||||
| Total VLDL-P‡ | 39.7±18.6 | 47.9±24.3 | 46.3±32.5 | 43.6±34.4 | 0.38 | 0.83 | 0.27 |
| Large VLDL-P (>60nm)‡ | 6.1±5.0 | 6.4±4.1 | 6.8±4.7 | 7.7±6.0 | 0.026 | 0.65 | 0.77 |
| Medium VLDL-P (35–60nm)‡ | 11.5±9.7 | 12.2±11.0 | 16.7±17.0 | 14.2±14.6 | 0.30 | 0.69 | 0.81 |
| Small VLDL-P (27–35nm)‡ | 23.5±14.5 | 30.3±16.6 | 24.3±20.9 | 23.2±24.2 | 0.45 | 0.49 | 0.092 |
| LDL Particles (nmol/L) | |||||||
| Total LDL-P | 1182.3±402.1 | 1239.2±400.4 | 1343.2±284.4 | 1331.1±253.3 | 0.79 | 0.17 | 0.41 |
| IDL-P (23–27nm) | 205.4±104.9 | 167.9±106.1 | 242.5±152.0 | 234.3±183.7 | 0.43 | 0.10 | 0.51 |
| Large LDL-P (21.2–23nm) | 461.7±246.1 | 462.8±236.9 | 450.9±285.0 | 465.6±289.2 | 0.13 | 0.99 | 0.88 |
| Small LDL-P (18–21.2nm)‡ | 389.6±292.2 | 477.4±289.6 | 502.8±245.4 | 485.7±275.4 | 0.85 | 0.35 | 0.022 |
| HDL Particles (nmol/L) | |||||||
| Total HDL-P | 32.7±3.2 | 32.3±4.5 | 30.6±5.2 | 31.1±5.4 | 0.35 | 0.43 | 0.29 |
| Large HDL-P (9.4–14nm) | 4.6±2.7 | 4.9±3.1 | 4.0±2.0 | 4.2±2.4 | 0.13 | 0.51 | 0.99 |
| Medium HDL-P (8.2–9.4nm)‡ | 8.6±5.0 | 8.8±7.5 | 9.2±6.3 | 9.2±5.1 | 0.69 | 0.69 | 0.6 |
| Small HDLP (7.3–8.2nm)‡ | 19.1±4.9 | 18.1±6.4 | 16.9±4.4 | 17.2±5.7 | 0.93 | 0.52 | 0.3 |
| Mean Particle Size (nm) | |||||||
| VLDL | 53.5±10.2 | 52.6±7.9 | 53.4±9.5 | 55.4±9.5 | 0.46 | 0.71 | 0.25 |
| LDL | 21.0±0.6 | 20.8±0.7 | 20.8±0.8 | 20.9±0.8 | 0.078 | 0.80 | 0.077 |
| HDL | 9.0±0.4 | 9.0±0.5 | 9.0±0.3 | 9.0±0.4 | 0.021 | 0.62 | 0.98 |
| Derived Concentrations (mg/dL) | |||||||
| Total Triglycerides | 117.7±50.9 | 125.0±53.5 | 131.8±57.7 | 135.3±66.1 | 0.59 | 0.51 | 0.87 |
| VLDL Triglycerides‡ | 78.4±43.0 | 84.5±45.1 | 86.7±51.5 | 90.3±58.6 | 0.19 | 0.99 | 0.76 |
| Total Cholesterol | 172.7±36.2 | 175.9±37.6 | 183.3±35.6 | 175.9±34.8 | 0.72 | 0.27 | 0.77 |
| LDL-C | 112.4±34.7 | 113.1±35.0 | 124.6±33.2 | 123.9±29.2 | 0.84 | 0.16 | 0.94 |
| HDL-C | 50.3±10.3 | 50.2±11.5 | 47.5±9.0 | 47.2±10.9 | 0.23 | 0.53 | 0.84 |
| Other | |||||||
| oxLDL (U/L)‡ | 70.0±25.6 | 74.3±19.1 | 78.0±20.7 | 69.3±15.4 | 0.99 | 0.54 | 0.019 |
‡
Untransformed Pre and Post data are shown for clarity even though the data required transformation for the statistical analysis of these variables.