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. 2019 Nov 18;22(1):1–9. doi: 10.1016/j.neo.2019.08.002

Fig. 4.

Fig. 4

T0901317 promotes cholesterol efflux by up-regulating ABCA1. (A-B) Quantification of free (A) and total (B) cytoplasmic cholesterol in MHCC97H cells after combination therapy. (C) Western blot analysis of MET and EGFR in lipid rafts in MHCC97H cells incubated in SOR with/without T09. (D-E) Quantification of MET (D) and EGFR (E) in lipid rafts in MHCC97H cells in (C). Expression level in CTRL group was standardized as 100%. (F-G) Quantitative real-time PCR (F) or western blot (G) of ABCA1 expression in MHCC97H cells after combination therapy. (H) Relative cell viabilities of MHCC97H cells treated by SOR, SOR with T09, and combination therapy with Cholesterol (Chol). (H) Effects of T09, SOR, and Chol on MET/EGFR pathways in MHCC97H cells. N ≥ 3, *P < .05, **P < .01, ***P < .001, ****P < .0001.