Skip to main content
. Author manuscript; available in PMC: 2020 Jan 12.
Published in final edited form as: Eur Respir J. 2019 Dec 12;54(6):1900378. doi: 10.1183/13993003.00378-2019

Figure 5: Small molecule Hif2 inhibitor PT2567 significantly attenuates early events in hypoxia-exposed adult rats at 4 days.

Figure 5:

Sprague Dawley rats were housed in chambers under normoxia or hypoxic conditions for four days. Rats were dosed with vehicle or PT2567 as described in Figure 4. After 4 days, endpoint measurements for the experimental animals were conducted (A–C). A) Mean Pulmonary Arterial Pressure. B) Ratio of weight of right ventricle versus weight of left ventricle. C) Representative images of pulmonary vessels stained with anti-macrophages/monocytes antibody, clone ED-1 (Top), anti-Ki67 antibody (Middle), or anti-Tenascin C antibody (Bottom). The levels of CD68, CCNA1, and TNC mRNAs in lungs of indicated rats were also shown (right). Statistical significance determined by 2-way ANOVA (A, B) or by t-test (C).