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. 2019 Nov 27;13:100187. doi: 10.1016/j.lrr.2019.100187

Fig. 3.

Fig 3

Downstream signaling of FLT3-ITD at the plasma membrane. FLT3-ITD at the plasma membrane is responsible for activation and phosphorylation of AKT, ERK1/2, GSK3β and STAT5, resulting in activation and production of DNA-damaging NOX4D-generated H2O2 [20, 21].