Table 3.
Antipyretic effects of dichloromethane leaf extract of E. globulus on turpentine-induced pyrexia in rat.
| Group | Treatment | Percentage change in rectal temperatures (ºC) |
||||
|---|---|---|---|---|---|---|
| 0hr | 1hr | 2hr | 3hr | 4hr | ||
| Normal control | DMSO | 100.00 ± 0.00 | 99.89 ± 0.13a (0.11) | 100.16 ± 0.22a (-0.16) | 99.78 ± 0.13a (0.22) | 99.89 ± 0.18a (0.11) |
| Negative Control | Turpentine + DMSO | 100.00 ± 0.00 | 100.42 ± 0.06a (-0.42) | 100.16 ± 0.10a (-0.57) | 100.68 ± 0.18b (-0.68) | 100.52 ± 0.12a (-0.52) |
| Positive Control | Turpentine + Aspirin | 100.00 ± 0.00 | 98.07 ± 0.07cd (1.93) | 97.55 ± 0.15bc (2.45) | 96.82 ± 0.12cde (3.18) | 95.31 ± 0.16d (4.69) |
| DCM: leaf Extract | Turpentine + 25 mg/kg bw | 100.00 ± 0.00 | 98.96 ± 0.08b (1.04) | 98.18 ± 0.23b (1.82) | 97.46 ± 0.25c (2.54) | 97.04 ± 0.26b (2.96) |
| Turpentine + 50 mg/kg bw | 100.00 ± 0.00 | 98.53 ± 0.06bc (1.47) | 97.91 ± 0.17b (2.09) | 97.28 ± 0.07cd (2.72) | 96.28 ± 0.13bc (3.72) | |
| Turpentine + 100 mg/kg bw | 100.00 ± 0.00 | 98.49 ± 0.10bc (1.51) | 97.44 ± 0.05bcd (2.56) | 96.60 ± 0.01de (3.40) | 95.98 ± 0.10cd (4.02) | |
| Turpentine + 150 mg/kg bw | 100.00 ± 0.00 | 98.13 ± 0.15cd (1.87) | 96.94 ± 0.05cd (3.06) | 96.37 ± 0.09e (3.63) | 95.53 ± 0.07cd (4.47) | |
| Turpentine + 200 mg/kg bw | 100.00 ± 0.00 | 97.57 ± 0.10d (2.43) | 96.80 ± 0.06cd (3.20) | 96.13 ± 0.08e (3.87) | 95.20 ± 0.07d (4.80) | |
| Turpentine + 250 mg/kg bw | 100.00 ± 0.00 | 97.71 ± 0.05d (2.29) | 96.73 ± 0.07d (3.27) | 96.41 ± 0.05e (3.59) | 95.17 ± 0.10d (4.83) | |
Descriptive statistics are expressed as mean ± SEM for 5 rats per group. Values with a similar superscript letter are statistically insignificant (p > 0.005) along the same column by one-way ANOVA followed by Tukey's post hoc test. Aspirin = 100 mg/kg body weight; DMSO = 10%; Turpentine = 20%; bw = body weight. The figures in brackets represent mean % inhibition.