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. 2019 Aug 13;7(6):379–395. doi: 10.1093/gastro/goz032

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© The Author(s) 2019. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Low-grade dysplasia in inflammatory bowel disease (IBD)- and Barrett’s esophagus (BE)-surveillance biopsies. (A) and (B) IBD colonic biopsy shows focal area resembling tubular adenoma, consisting of glands lined by enlarged, stratified, hyperchromatic nuclei (H&E stain; (A) magnification 100×; (B) magnification 200×). The changes extend to the surface epithelium (lack of surface maturation). There is no architectural complexity, loss of nuclear polarity, or significant pleomorphism—features to suggest HGD. (C) and (D) Similar features are present in a BE-surveillance biopsy, supporting the diagnosis of low-grade dysplasia (H&E stain; (C) magnification 40×; (D) magnification 100×).