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. 2019 Aug 13;7(6):379–395. doi: 10.1093/gastro/goz032

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© The Author(s) 2019. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Chronic colitis with high-grade dysplasia. (A) and (B) This biopsy shows an area consisting of atypical glands lined by enlarged dark nuclei without surface maturation (H&E stain; (A) magnification 100×; (B) magnification 200×). The adjacent fragment provides an internal negative control. (C) and (D) This colon biopsy shows architectural and cytologic features of high-grade dysplasia (H&E stain; (C) magnification 40×; (D) magnification 200×). There is focal cribriforming, nuclear pleomorphism, and loss of nuclear polarity.