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. 2019 Aug 13;7(6):379–395. doi: 10.1093/gastro/goz032

Figure 5.

Figure 5.

Barrett’s esophagus with high-grade dysplasia. (A) and (B) This biopsy shows focus of atypical and crowded glands lined by cells containing enlarged and hyperchromatic nuclei, extending to the surface ((A) H&E stain, magnification 200×). There is a high nuclear/cytoplasmic ratio and nuclear pleomorphism ((B) H&E stain, magnification 400×). (C) and (D) This biopsy shows proliferation of glands with marked architectural complexity and enlarged and hyperchromatic nuclei. There is no surface maturation (H&E stain; (C) magnification 40×; (D) magnification 200×).