Table 3.
Location of biopsy | Endoscopic finding | Pathologic diagnosis | Implications |
---|---|---|---|
Outside of colitis region | Polyp or sessile lesions | Sporadic adenoma, hyperplastic polyp, or sessile serrated polyp | Complete removal with routine IBD annual surveillance |
Inside of colitis region | Polyp (resectable) | Polypoid LGD or HGD | Complete removal with intensified surveillance |
Polyp (unresectable) on conventional colonoscopy | Polypoid LGD or HGD (should be confirmed by another GI pathologist) | IBD expert referral with chromoendoscopy or colonoscopy of high resolution:
|
|
Visible but unresectable mass/lesion (elevated, flat, depressed) or invisible on conventional colonoscopy | LGD, HGD, or invasive adenocarcinoma (should be confirmed by another GI pathologist) | Focal LGD: intensified surveillance or referral to an IBD center for a repeat colonoscopy with high resolution and/or chromoendoscopy or colectomy (depending on clinical and endoscopic suspicion) HGD: colectomy Invasive adenocarcinoma: colectomy | |
Sessile lesion | Sessile serrated polyp | Complete removal with routine IBD annual surveillance |
IBD, inflammatory bowel disease; LGD, low-grade dysplasia; HGD, high-grade dysplasia.