Table 6.
Summary of rs733618 and rs16840252-related disease.
| SNP | Disease | Subjects and Results | Ref. |
|---|---|---|---|
| rs733618 | Systemic lupus | Asian: | [23] |
| erythematosus | C allele was strongly associated with SLE and also CC genotype was significantly associated with the risk of SLE, p = 0.000). | ||
| Breast cancer | Chinese: | [27] | |
| CC genotype and C allele showed an increased risk of breast cancer (p = 0.030, odds ratio (OR) = 1.457, 95% confidence internal (CI) 1.036–2.051; p = 0.024, OR = 1.214, 95% CI 1.026–1.436, respectively). | |||
| Polycystic ovary syndrome | Chinese Han population: | [28] | |
| significantly different between case and control groups in either genotypic or allelic distribution, p = 0.01 and 0.009, respectively. | |||
| Survival in patients with sepsis | Adult Caucasian patients with sepsis: | [29] | |
| lower 90-day mortality was observed for Trs733618 Ars231775 Ars3087243 haplotype-negative patients than for patients carrying the TAA haplotype, p = 0.0265. | |||
| Survival in patients with multiple myeloma receiving bortezomib-based regimens | Unrelated Chinese Han population: GG genotype reduced the progression-free survival and the overall survival of patients with multiple myeloma who received bortezomib-based therapy, p = 0.002. | [30] | |
| Non-small-cell lung cancer | Chinese: | [31] | |
| (NSCLC) | T > C polymorphism was associated with the development of NSCLC in ≥60 years and even drinking subgroups. | ||
| Myasthenia gravis (MG) | Chinese Han population: | [32] | |
| C allele were more frequent in MG patients, p = 0.042. | |||
| Urinary schistosomiasis | Gabonese children: | [33] | |
| T allele and TT genotype were significantly overrepresented in the patient group, p = 0.001. | |||
| Lymphatic filariasis (LF) | Sarawak, Malaysia: | [34] | |
| CT genotype (p = 0.02) and those with combined minor allele C carriers (CT + CC; p = 0.01) exhibited a significantly decreased risk for LF. | |||
| rs16840252 | Colorectal cancer | Chinese: | [35] |
| polymorphism was associated with an increased risk of colon cancer in homozygote model p = 0.040 and recessive model p = 0.037. | |||
| Recurrent schizophrenia | Chinese Han population: | [36] | |
| A significant association with schizophrenia, p (allele) = 0.0081, p (genotype) = 0.0117. |