Table 2.
Association between intervention with vitamin D and GDM outcomes in meta-analyses of RCTs.
| References | No. Studies | No. Participant | Outcomes | I2 |
|---|---|---|---|---|
| Pérez-Lòpez, et al. 2015 [85] | 13 | 2299 | Circulating 25-OHD: (MD 66.46, CI 95% 66.22 to 66.71) | 100.0% |
| Preeclampsia: (RR 0.88, CI 95% 0.51 to 1.52) | 24.0% | |||
| Gestational diabetes: (RR 1.05, CI 95% 0.60 to 1.84) | 0.0% | |||
| Small for gestational age: (RR 0.78, CI 95% 0.50 to 1.21) | 15% | |||
| Low birth weight: (RR 0.72, CI 95% 0.44 to 1.16) | 0.0% | |||
| Preterm birth: (RR 1.26, CI 95% 0.60 to 2.63) | 0.0% | |||
| Birth weight: (MD 107.60, CI 95% 59.86 to 155.33) | 0.0% | |||
| Birth length: (MD 0.30, CI 95% 0.19 to 0.41) | 84.0% | |||
| Cesarean section: (RR 0.94, CI 95% 0.78 to 1.13) | 0.0% | |||
| Palacios, et al. 2016 [84] | 7 | 868 | Serum 25-OHD: (MD 54.73, CI 95% 23.76 to 70.39) | 99.0% |
| Preeclampsia: (RR 0.52, CI 95% 0.25 to 1.05) | 15.5% | |||
| Gestational diabetes: (RR 0.43, CI 95% 0.05 to 3.45) | NR | |||
| de-Regil, et al. 2016 [86] | 3 | 273 | Circulating 25-OHD: (MD 47.08, CI 95% 36.60 to 72.86) | 98.0% |
| Low birth weight: (RR 0.48, CI 95% 0.23 to 1.01) | 53.0% | |||
| Birth length: (MD 0.97, CI 95% −0.41 to 2.34) | 84.0% | |||
| Head circumference: (MD 0.43, CI 95% 0.06 to 0.79) | 50.0% | |||
| Birth weight: (MD 39.55, CI 95% −240.68 to 319.78) | 96.0% | |||
| Akbari, et al. 2017 [87] | 11 | 371 | HOMA-IR: (SMD −0.66, CI 95% −1.14 to -0.18) | 57.4% |
| QUICKI: (SMD 0.73, CI 95% 0.26 to 1.20) | 64.9% | |||
| HOMA-B: (SMD −0.52, CI 95% −0.79 to −0.25) | 0.0% |
OR: Odds Ratio, RR: Risk Ratio, MD: Mean Difference, SMD: Standardized Mean Difference, I2: Heterogeneity, NS: Not Significant.