Table 2.
Comparisons of acid-base variables in septic patients (n = 79) *,†.
| Variable | Group A (n = 52) | Group B (n = 27) | ||||
|---|---|---|---|---|---|---|
| Admission | Sepsis Remission | p Value | Admission | Sepsis Deterioration | p Value | |
| pHa | 7.37 ± 0.073 | 7.47 ± 0.05 | <0.001 | 7.35 ± 0.09 | 7.23 ± 0.16 | 0.001 |
| pHv | 7.34 ± 0.07 | 7.42 ± 0.05 | <0.001 | 7.32 ± 0.08 | 7.20 ± 0.15 | <0.001 |
| PCO2a (mmHg) | 45.3 ± 10.3 | 39.1 ± 9.7 | 0.001 | 43.4 ± 7.7 | 45.1 ± 12.4 | 0.61 |
| PCO2v (mmHg) | 51.8 ± 10.3 | 46.5 ± 10.1 | 0.010 | 51.1 ± 7.6 | 51.4 ± 11.0 | 0.91 |
| [HCO3–a] (mEq/L) | 25.4 ± 4.9 | 27.3 ± 5.1 | 0.02 | 23.6 ± 5.4 | 19.5 ± 6.8 | 0.03 |
| [HCO3–v] (mEq/L) | 27.0 ± 4.8 | 29.3 ± 4.9 | 0.005 | 25.9 ± 5.8 | 20.7 ± 6.7 | 0.008 |
| [Laca] (mEq/L) | 1.3 ± 0.5 | 1.1 ± 0.4 | 0.02 | 2.4 ± 1.3 | 5.2 ± 3.8 | 0.001 |
| [Lacv] (mEq/L) | 1.3 ± 0.6 | 1.2 ± 0.4 | 0.1 | 2.5 ± 1.3 | 4.9 ± 3.4 | 0.002 |
| AGa (mEq/L) | 13.27 ± 2.94 | 12.58 ± 3.34 | 0.07 | 14.95 ± 3.19 | 15.38 ± 6.36 | 0.61 |
| AGv (mEq/L) | 13.39 ± 2.95 | 12.55 ± 3.04 | 0.07 | 14.55 ± 3.22 | 15.62 ± 6.29 | 0.58 |
| BEa (mEq/L) | –0.29 ± 4.75 | 3.20 ± 4.48 | 0.001 | –1.79 ± 6.24 | –8.04 ± 8.19 | 0.004 |
| BEv (mEq/L) | 0.68 ± 4.62 | 4.11 ± 4.33 | <0.001 | –0.41 ± 6.50 | –6.85 ± 9.14 | 0.006 |
| [Cla] (mEq/L) | 106.4 ± 5.7 | 105.7 ± 7.1 | 0.39 | 105. 1 ± 6.5 | 109.0 ± 4.0 | 0.005 |
| [Clv] (mEq/L) | 105.0 ± 5.7 | 104.0 ± 6.9 | 0.23 | 103.4 ± 6.9 | 107.8 ± 4.4 | 0.004 |
| [Naa] (mEq/L) | 139.5 ± 5.4 | 139.8 ± 5.0 | 0.78 | 137.8 ± 4.8 | 136.9 ± 3.8 | 0.54 |
| [Nav] (mEq/L) | 139.9 ± 5.4 | 140.1 ± 4.7 | 0.84 | 138.0 ± 5.1 | 137.1 ± 4.7 | 0.61 |
| SIDa (mEq/L) | 35.7 ± 4.6 | 36.8 ± 5.3 | 0.15 | 34.7 ± 5.5 | 27.4 ± 6.4 | <0.001 |
| SIDv (mEq/L) | 37.4 ± 4.5 | 38.8 ± 5.2 | 0.06 | 36.6 ± 6.1 | 29.1 ± 6.6 | 0.001 |
| SIDea (mEq/L) | 34.0 ± 4.7 | 35.6 ± 5.4 | 0.06 | 32.7 ± 5.6 | 27.5 ± 6.6 | 0.009 |
| SIDev (mEq/L) | 35.8 ± 4.5 | 37.6 ± 5.3 | 0.03 | 35.1 ± 6.1 | 28.7 ± 6.5 | 0.002 |
| SIGa (mEq/L) | 1.69 ± 3.17 | 1.24 ± 3.17 | 0.3 | 1.98 ± 2.59 | –0.15 ± 3.40 | 0.03 |
| SIGv (mEq/L) | 1.62 ± 2.67 | 1.22 ± 3.08 | 0.3 | 1.49 ± 2.73 | 0.34 ± 3.60 | 0.18 |
| ΔPCO2v-a (mmHg) | 6.47 ± 3.03 | 7.41 ± 3.24 | 0.05 | 7.71 ± 3.07 | 6.30 ± 3.23 | 0.04 |
* Values are mean ± SD; † (a) and (v) suffixes indicate measurements in arterial or central venous blood, respectively. PCO2: partial pressure of carbon dioxide; [HCO3-]: bicarbonate concentration; [Lac]: lactate concentration; AG: anion gap corrected for albumin; BE: base excess; [Cl]: chloride concentration; [Na]: sodium concentration; SID: apparent strong ion difference; SIDe: effective strong ion difference; SIG: strong ion gap; ΔPCO2v-a: central venous-arterial difference of carbon dioxide partial pressure.