Table 5.
Cox proportional hazards regression for fatal ICU outcome (n = 96).
| Univariable Models | Hazard Ratio | 95% Confidence Interval | p Value |
|---|---|---|---|
| Admission ΔPCO2/ΔpH (%) | 0.98 | 0.97–0.99 | 0.01 |
| Admission ΔPCO2/Δ[H+] (%) | 1.39 | 1.09–1.77 | 0.008 |
| Remission/deterioration ΔSID/ΔpH (%) | 0.98 | 0.96–0.99 | 0.03 |
| Remission/deterioration ΔSID/Δ[H+] (%) | 1.46 | 1.07–2.00 | 0.02 |
| Remission/deterioration ΔPCO2/Δ[H+] (mmHg/nmol/L) |
0.41 | 0.27–0.64 | <0.001 |
| Models adjusted for SOFA score * | Hazard ratio | 95% confidence Interval | p value |
| Admission ΔPCO2/ΔpH (%) | 0.98 | 0.97–0.99 | 0.02 |
| Admission ΔPCO2/Δ[H+] (%) | 1.27 | 0.98–1.65 | 0.07 |
| Remission/deterioration ΔPCO2/Δ[H+] (mmHg/nmol/L) | 0.56 | 0.33–0.96 | 0.03 |
* SOFA score at all time points (admission, sepsis remission/ deterioration) was an independent predictor of death in the ICU with hazard ratios ranging between 1.21 and 1.43 with high statistical significance (p values ranging between <0.001 and 0.003). Δ corresponds to the difference of the related variable between central venous and arterial blood; PCO2: partial pressure of carbon dioxide; [H+]: hydrogen cation concentration; SID: apparent strong ion difference; SOFA: sequential organ failure assessment.