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. 2019 Oct 28;8(11):1330. doi: 10.3390/cells8111330

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Tumor treatment for long periods with si-hVDAC1 alters the expression of signaling-, development-, differentiation-, and microenvironment-related proteins, relative to their expression following short-term treatment. Quantitative analysis of the LC-HR MS/MS data. (A) Differentially expressed proteins associated with signaling, development, and differentiation between tumors treated with si-hVDAC1 for short and long periods are presented as fold change of the expression in si-VDAC1-TTs, relative to si-NT-TTs. Differentially expressed proteins of mouse (B) and human (C) origin associated with the microenvironment in tumors treated with si-hVDAC1 for short and long periods, presented as fold change of the expression in si-hVDAC1-TTs, relative to si-NT-TTs. (■) and () indicate short-term and long-term treatment with si-hVDAC1, respectively. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.

Inline graphic — Tumor treatment for long periods with si-hVDAC1 alters the expression of signaling-, development-, differentiation-, and microenvironment-related proteins, relative to their expression following short-term treatment. Quantitative analysis of the LC-HR MS/MS data. (A) Differentially expressed proteins associated with signaling, development, and differentiation between tumors treated with si-hVDAC1 for short and long periods are presented as fold change of the expression in si-VDAC1-TTs, relative to si-NT-TTs. Differentially expressed proteins of mouse (B) and human (C) origin associated with the microenvironment in tumors treated with si-hVDAC1 for short and long periods, presented as fold change of the expression in si-hVDAC1-TTs, relative to si-NT-TTs. (■) and () indicate short-term and long-term treatment with si-hVDAC1, respectively. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.