Differentially expressed protein synthesis and degradation-, epigenetic regulation, DNA structure-, and DNA replication-related proteins following short- and long-term treatments with si-VDAC1 or si-NT. Quantitative analysis of the LC-HR MS/MS data. Differentially expressed proteins of mouse (A) and human (B) origin associated with the microenvironment in tumors treated with si-hVDAC1 for short and long periods, are presented as fold change of the expression in si-VDAC1-TTs, relative to si-NT-TTs. (■) and () indicate short-term and long-term treatment with si-hVDAC1, respectively. * p ≤ 0.05, ** p ≤ 0.01.