Table 1.
Differentially expressed proteins in TNBC PDX tumors with versus without CTCcls based on RPPA analysis.
| Antibody | Average Log2 Intensity on TNBC-PDX Tumors | p-Value | FDR q-Value | Expression Levels | FC | |
|---|---|---|---|---|---|---|
| CTCcl+ | CTCcl− | |||||
| * Bcl2 | 1.63 | −0.18 | <0.0001 | <0.0001 | ↑ | 3.5 |
| # ACC1 | −1.55 | 0.02 | <0.0001 | 0.0005 | ↓ | 0.3 |
*, significantly upregulated protein; #, significantly downregulated protein. Abbreviations: ACC1, acetyl CoA carboxylase-1; Bcl2, B-cell lymphoma 2; CTCcl, circulating tumor cell cluster; FC, fold change; FDR, false discovery rate; PDX, patient-derived xenograft; TNBC, triple-negative breast cancer; RPPA, reverse-phase protein array.