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Poorly-differentiated Pit1-lineage tumor. (a) These tumors have variable histology, usually formed of polygonal to spindle-shaped cells. (b) They have strong nuclear Pit1 reactivity. (c) Immunohistochemistry usually reveals variable staining patterns with scattered positivity for GH, PRL, TSH and alpha-subunit of glycoprotein hormones (shown). (d) These tumors usually also have variable expression of estrogen receptor and GATA-3.
