Table 3.
Median values with range observed before (MRI-T0) and during immunotherapy in High and Low NK patients.
| High/LowNK | aMRI-T0 | aMRI-T2 | aMRI-T4 | aMRI-T12 | |
|---|---|---|---|---|---|
| Median TV T1 CE (cm3) | HighNK | 3.2 (0–11.2) | 2.71 (0–38.34) | 3.3 (0–13.57) a | 0.94 (0–8.3) |
| LowNK | 5.7 (0.86–25.22) | 6.6 (1.1–27) | 7.5 (0.71–20.72) b | - | |
| rCBVmax | HighNK | 5.29 (0.56–10.55) | 3.29 (0.92–14.14) | 3.79 (0.76–10,04) | 2.6 (0.71–6.89) |
| LowNK | 5.25 (2.27–9,69) | 3.91 (1.81–7.52) | 4.85 (1.08–6.82) | - | |
| rADCmin | HighNK | 1.15 (0.82–1.47) c | 1.01 (0.76–1.51) d | 0.97 (0.67–1.34) e | 1.02 (0.85–1.32) |
| LowNK | 0.97 (0.69–1.61) | 1 (0.82–1.47) | 0.99 (0.7–1.11) | - | |
| ADCskewness | HighNK | 1.38 (0.99–3.15) | 1.62 (0.84–2.75) | 1.59 (0.71–2.1) | 1.79 (1.07–4.47) |
| LowNK | 1.95 (0.85–2.44) | 1.98 (1.4–2.3) | 1.73 (1.4–2.35) | - | |
| ADCmode (10−3 mm2/s) | HighNK | 1.22 (0.3–2) f | 1.24 (0.06–1.6) | 0.8 (0.2–1.5) | 1.1 (0.9–1.2) |
| LowNK | 0.8 (0.4–1.1) g | 1.24 (0.9–1.8) h | 1.3 (0.2–1) | - | |
| ADCmean (10−3 mm2/s) | HighNK | 1.4 (1–1.7) | 1.4 (0.8–1.7) | 1.4 (0.9–1.8) | 1.2 (0.9–1.9) |
| LowNK | 1.3 (1.1–1.6) i | 1.4 (1.3–1.6) l | 1.5 (1.2–1.7) m | - |
Note: a,b, p = 0.04; c,d, p = 0.003; c–e, p = 0.005; f,g, p = 0.03; g,h, p = 0.018; i–l, p = 0.018; i–m, p = 0.017.