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. 2019 Nov 2;8(11):1847. doi: 10.3390/jcm8111847

Figure 3.

Figure 3

Synthetic scheme of ODZ10117. Reagents and conditions: (a) bromoacetonitrile (1.0 equiv), K2CO3 (1.0 equiv), DMF, room temperature, 5 h, 96%; (b) hydroxylamine hydrochloride (1.3 equiv), Et3N (1.3 equiv), EtOH:H2O (9:1), 100°C, 1 h, 85%; (c) trichloroacetonitrile (1.0 equiv), p-toluenesulfonic acid monohydrate (0.5 equiv), zinc chloride (0.5 equiv), DMF, 80°C, 16 h, 53%.