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. 2019 Nov 2;8(11):1847. doi: 10.3390/jcm8111847

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ODZ10117 inhibits tumor growth and lung metastasis and increases survival in breast cancer xenograft model. (A–F) Syngeneic breast metastasis xenograft model was generated by injection of 4T1-Luc cells into the right fourth mammary fat pad of female BALB/c mice. Primary tumor growth is shown (A,B). Representative bioluminescence images of whole body (C). Kaplan-Meier survival graph of tumor-bearing mice (D). Lung metastatic tumor nodules were observed on the surface (upper) and bioluminescence images (bottom) of the lung (E) and lung nodules were counted (F). * p < 0.05 and ** p < 0.005 compared to the vehicle-treated group.