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Heterogeneity of blood vessels in the tumor microenvironment. During tumor progression, new blood vascular networks will be developed to provide nutrients and oxygen and remove the metabolic wastes. They can also interact with other types of cells within the vascular niche. Shown is the formation of several types of blood vessels through processes, including de novo arteriogenesis, venogenesis, vascular remodeling, angiogenesis, and vasculogenesis.
