Table 1.

Reported frequencies of ubiquitin-specific peptidase 8 (USP8)-mutation in patients with Cushing’s disease (CD) and their clinical characteristics.

Reincke M (2015) [27]	4/10 (40.0%)
Ma, Z.Y (2015) [26]	67/108 (62.0%)	smaller tumor size (p < 0.001), female sex (p = 0.01)
Hayashi K (2016) [25]	21/60 (35.0%)	female sex (p = 0.023), smaller tumor size (p = 0.0012), lower Knosp grade (p = 0.012), higher surgical remission rate (p = 0.001)
Faucz FR (2017) [33]	13/42 (31.0%) (pediatric patients)	later age (p = 0.03), lower body mass index z-score (p = 0.02), higher rate of recurrence or failure to cure (p = 0.009)
Albani A (2018) [32]	18/48 (37.5%)	younger age (p = 0.028), higher 24h-UFC level (p = 0.045), higher recurrence rate (p = 0.026), earlier recurrence (p = 0.019)
Bujko M (2019) [30]	15/28 (53.5%)
Losa M (2019) [29]	22/92 (23.9%)	female sex (p < 0.05), higher surgical remission rate (p = 0.01)
Wanichi IQ (2019) [28]	11/47 (23.7%)	female sex (p < 0.00001), lower 24h-UFC level (p ≤ 0.017), higher surgical remission rate (p < 0.00001)