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NO-activated sGC/PKG pathway regulates the insulin response in hepatocytes in vitro. Impact on insulin signaling in Huh7 cells (A) inhibiting the sGC/PKG pathway using KT5823 (1 µM) in the presence or absence of arginine (1 mM) or NONOate (1 mM) for 24 h; and (B) activating the sGC/PKG pathway using 8-pCPT-cGMP (100 µM) and BAY41-2272 (2 µM) for 24 h. £ and #, p < 0.05 vs. control.
