Table 1.

PICOS criteria (participants, interventions, comparisons, outcomes, and study design) used to define the research question.

Participants	Humans aged ≥ 18 years of both sexes with any of these clinical conditions: healthy, hypertension or metabolic syndrome
Interventions	Supplementation with (i) fruits or (ii) vegetables or (iii) fruit and vegetable concentrates
Comparisons	Placebo or No treatment
Outcomes	Total cholesterol; Low-density lipoprotein; Plasmatic homocysteine; Systolic blood pressure; Body mass index
Study Design	Interventional