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. 2019 Nov 12;8(11):1422. doi: 10.3390/cells8111422

Figure 4.

Figure 4

Late oligodendrocyte progenitor cells (OPC) differentiation after 14 days of multifactor treatment. (a) Heatmap showing the influence of platelet-derived growth factor subunit A dimer (PDGF–AA) and fibroblast growth factor 2 (FGF2) on late differentiation measured as percent of area positive for myelin basic protein (MBP). (b). Representative microscopy images showing the MBP expression. (c) Heatmap showing the influence of bone morphogenetic protein 2 (BMP2) on MBP expression. (d) Representative microscopy images of PDGF–AA and FGF2 concentrated at 20 ng/mL and with BMP2 levels of 0–100 ng/mL. (e) Heatmap showing the influence of BMP4 on MBP expression. (f) Representative microscopy images of PDGF–AA and FGF2 concentrated at 20 ng/mL and with BMP4 levels of 0–100 ng/mL.