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. 2019 Nov 18;8(11):1460. doi: 10.3390/cells8111460

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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β-catenin overexpression abolishes the effect of carbamazepine on adipogenesis. (A) Cells treated with vehicle or 40 μM carbamazepine were differentiated after β-catenin overexpression and stained with Oil Red O. (Top) Photomicrographs of entire wells; (Bottom) Photomicrographs of stained cells (scale bar, 100 μm). (B) PPARγ mRNA levels were analyzed by qRT-PCR (n = 5 per group). (C) Protein levels of Wnt/β-catenin signaling and PPARγ in 3T3-L1 cells overexpressing β-catenin after carbamazepine treatment were analyzed by Western blot. (D) mRNA levels of adipogenic genes in 3T3-L1 cells overexpressing β-catenin after carbamazepine treatment were analyzed by qRT-PCR (n = 5 per group). Values are mean ± SEM. * P < 0.05; ** P < 0.01.