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. 2019 Oct 29;8(11):1337. doi: 10.3390/cells8111337

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Role of Akt1 and Akt2 in HSC proliferation and migration. (A) Cell proliferation was performed by MTT assay of human HSC transfected with siAkt1 or siAkt2 and treated for 3 h with acetaldehyde, LPS, or both. Quantitative qPCR analysis of (B) c-Myc and (C) Cyclin D1 was performed with total RNA obtained from human HSCs. All values are means of triplicate experiments ± SE after correcting for the expression of S18. (D) Cell migration was determined after wounding a confluent culture and measuring the gap area at the time points indicated in the figure. Panel E shows percent of open area. Values are means of triplicate experiments ± S.E. * p < 0.05 as compared to control, ** p < 0.05 as compared to acetaldehyde and LPS.