Table 3.
Differences in clinical and laboratory characteristics among quartiles of DR (median value: 0.20 (0.091–0.266).
| Q1 (n = 31) | Q2 (n = 26) | Q3 (n = 35) | Q4 (n = 29) | p-Value | |
|---|---|---|---|---|---|
| Age (years) | 81 (76–87) | 83 (76–88) | 81 (78–85) | 79 (77–85) | 0.76 |
| Gender male (%) | 32 | 42 | 40 | 55 | 0.34 |
| Renal function biomarkers at admission | |||||
| Creatinine (mg/dL) | 1.70 (1.10–1.80) | 1.70 (1.27–2.12) | 1.40 (1.20–1.80) | 1.50 (1.10–1.70) | 0.33 |
| eGFR (ml/min/1.73 m2) | 39 (32–58) | 41 (24–50) | 45 (38–52) | 49 (38–60) | 0.15 |
| BUN (mg/dL) | 79 (56–104) | 87 (59–105) | 67 (42–106) | 73 (48–117) | 0.68 |
| Renal function biomarkers after treatment | |||||
| Creatinine (mg/dL) | 1.50 (1.40–1.90) | 1.55 (1.27–2.30) | 1.40 (1.20–1.60) | 1.50 (1.20–1.80) | 0.17 |
| eGFR (ml/min/1.73 m2) | 36 (30–51) | 43 (27–50) | 49 (44–51) | 47 (38–54) | 0.01 |
| Admission BNP (pg/mL) | 753 (536–1214) | 861 (563–1436) | 875 (585–1270) | 887 (452–1401) | 0.97 |
| Mean daily urine output (ml) | 1900 (1500–2250) | 2550 (1850–3100) | 2100 (1700–2500) | 2400 (1850–2800) | 0.01 |
| Diuretic in-hospital IV dosage (mg/die) | 200 (175–225) | 200 (125–250) | 120 (80–125) | 100 (71–125) | <0.001 |
| LVEF (%) | 30 (25–35) | 30 (25–35) | 35 (30–40) | 40 (35–40) | <0.001 |
| Additional hypertonic saline solution (%) | 26 | 54 | 23 | 31 | 0.06 |
| Inotropes agents administration (%) | 16 | 42 | 20 | 28 | 0.12 |
| Risk factors (%) | |||||
| Diabetes Mellitus | 71 | 27 | 23 | 34 | <0.001 |
| Hypertension | 48 | 65 | 31 | 45 | 0.07 |
| Dyslipidemia | 48 | 77 | 40 | 28 | 0.002 |
| CAD | 87 | 58 | 43 | 66 | 0.003 |
| Atrial fibrillation (%) | 65 | 35 | 11 | 34 | <0.001 |
| CKD (%) | 58 | 58 | 34 | 41 | 0.15 |
| BNP decrease ≥ 30% after treatment (%) | 48 | 54 | 49 | 48 | 0.97 |
| WRF (%) | 26 | 19 | 23 | 45 | 0.13 |
| Persistence of congestion after treatment (%) | 26 | 23 | 40 | 24 | 0.39 |
| 180 days CV death/HF rehospitalization (%) | 71 | 73 | 37 | 34 | 0.001 |
Abbreviations: atrial fibrillation (AF); B-type natriuretic peptide (BNP); blood urea nitrogen (BUN); chronic kidney disease (CKD); coronary artery disease (CAD); diuretic response (DR); estimated glomerular filtration rate (eGFR); left ventricular ejection fraction (LVEF).