Table 1.
Transcriptomic analysis of HOXA9-regulated genes by RNA-Seq in cutaneous squamous cell carcinoma (cSCC) cells. Over-represented categories by GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of differently-expressed genes. BP: biological process. The “NF-kappaB signaling pathway”, “Apoptosis” and “Regulation of autophagy” were highlighted.
| Category | GO ID | Term | p-Value |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0045893 | Positive regulation of transcription, DNA-templated | 5.65 × 10−12 |
| GOTERM_BP_DIRECT | GO:0043065 | Positive regulation of apoptotic process | 1.58 × 10−9 |
| GOTERM_BP_DIRECT | GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 2.14 × 10−8 |
| GOTERM_BP_DIRECT | GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | 2.19 × 10−8 |
| GOTERM_BP_DIRECT | GO:0006915 | Apoptotic process | 4.17 × 10−8 |
| GOTERM_BP_DIRECT | GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | 5.28 × 10−8 |
| GOTERM_BP_DIRECT | GO:0042981 | Regulation of apoptotic process | 5.16 × 10−6 |
| GOTERM_BP_DIRECT | GO:1902041 | Regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.12 × 10−4 |
| GOTERM_BP_DIRECT | GO:0043068 | Positive regulation of programmed cell death | 1.57 × 10−3 |
| GOTERM_BP_DIRECT | GO:0016236 | Macroautophagy | 1.78 × 10−2 |
| KEGG_PATHWAY | hsa05200 | Pathways in cancer | 6.91 × 10−12 |
| KEGG_PATHWAY | hsa04064 | NF-kappaB signaling pathway | 2.63 × 10−9 |
| KEGG_PATHWAY | hsa04210 | Apoptosis | 1.08 × 10−2 |
| KEGG_PATHWAY | hsa04140 | Regulation of autophagy | 4.96 × 10−2 |