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. 2019 Oct 29;8(11):519. doi: 10.3390/antiox8110519

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Strategies for vitamin C biofortification. Modulation of light intensity and quality can be used to obtain vitamin C enrichment in crops. The overexpression of single or multiple genes belonging to the biosynthetic and recycling pathways, as well as to the regulatory network, represents a good tool for vitamin C biofortification. Vitamin C accumulation can be controlled by modulating translation by the editing of the uORF in the GGP gene. Finally, vitamin C biofortification can be obtained by plant breeding that exploits candidate genes in the quantitative trait locus (QTL) associated with high vitamin C content (more details are provided in the text).