Figure 1.

Effect of platelet aggregation with addition of rivaroxaban and anti-tissue factor pathway inhibitor (TFPI) on human platelet rich plasma (PRP) in thrombin generation (TG). Representative TG curves in PRP or PRP after aggregation (agPRP) triggered with 2 µg/mL of collagen with and without addition or 50 ng/mL of rivaroxaban (A) and inhibition of TFPI (anti-TFPI 5 µg/mL) (B). Lag time of thrombin generation for the different conditions (C,D). Velocity of thrombin generation under the different conditions (E,F). Results are presented as median (min-max). ** p < 0.01, *** p < 0.001, vs. PRP; ## p < 0.01, ### p < 0.001, vs. agPRP, n = 16 per group for left panels and n = 5 for right panels.