Figure 1.

Targeting the stress response protein NUPR1 is a promising therapy for treating cancer. Pancreatic cancer cells are extremely challenged by a stressful environment due to a poor concentration of nutrient and oxygen, among other factors. In order to adapt themselves and survive, tumor cells activate stress response pathways overexpressing stress proteins such as NUPR1, which is constantly present in the tumor tissue. Our strategy is focused on targeting NUPR1 to induce cancer cell death as a therapeutic treatment for cancer.