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. 2019 Nov 17;8(11):1453. doi: 10.3390/cells8111453

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ZZW-115 hampered the nuclear translocation of NUPR1. (Left panel) NUPR1 is a nuclear protein with a predicted NLS. This part of the protein binds to importins and facilitates its translocation from the cytoplasm to the nucleus, through the nuclear pore complex. Thus, NUPR1 exhibits a nuclear localization (as showed in this immunofluorescence), where it can develop its activity and promote tumor progression. (Right panel) Nuclear magnetic resonance data indicated that ZZW-115 binds to NUPR1 in the residue Thr68 [35,37], located within the NLS. Thus, pharmacological inhibition of NUPR1 hampered the interaction with importin and its translocation to the nucleus (as showed in this immunofluorescence). After ZZW-115 treatment, NUPR1 was located in the perinuclear and cytoplasmic area, and inhibition of the nuclear activity of NUPR1 induced tumor growth arrest.