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. 2019 Oct 28;8(11):514. doi: 10.3390/antiox8110514

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biomarkers in plasma and heart from rats with preestablished cardiovascular disease or pharmacologically induced oxidative stress. Markers of oxidative stress (3-NT, MDA, 4-HNE) and inflammation (IL-6) were increased in plasma (A–C) and heart (D–F) of hypertensive, diabetic and nitrate tolerant rats as compared to control animals. Original blots are shown on the right for 4 technical replicates per group (G–I). Data are mean ± SD of 7 (Ctr) and 3 (AT-II, STZ, GTN) rats per group. Each single animal data point was generated from 2–4 technical replicates. * p < 0.05 vs. control group.