Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 12;8(11):1424. doi: 10.3390/cells8111424

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic depiction of oligodendroglial lineage markers specific for different developmental stages from neuronal progenitor cells (NPC) to myelinating oligodendrocyte (OL). A2B5 recognises progenitor cells, NPC and oligodendrocyte progenitor cells (OPC), while oligodendroglial cell lineage markers Olig1 and 2 as well as Sox10 and Nkx2.2 are expressed in all cells of the lineage, OPC and pre-oligodendrocytes (pre-OL) are characterised by PDGFR-α and NG2 expression. PLP, O4, O1 and CNPase are expressed during transition from progenitor to differentiated oligodendrocytes, while differentiated, axon-myelinating oligodendrocytes are characterised by myelin protein expression (MBP, MAG, MOG, GalC). NPC: neuronal progenitor cell; OPC: oligodendrocyte progenitor cell; OL: oligodendrocyte; PDGFR-α: platelet-derived growth factor receptor A; NG2: neuron-glial antigen 2; PLP: proteolipid protein; CNPase: 2’,3’-Cyclic-nucleotide 3’-phosphodiesterase; MBP: myelin basic protein; MAG: myelin associated glycoprotein; MOG: myelin-oligodendrocyte glycoprotein; GalC: galactocerebroside.