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. 2019 Nov 3;8(11):1380. doi: 10.3390/cells8111380

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Wnt signaling in cancers. Deregulation of Wnt signaling components is involved in selected cancers (brain cancer, leukemia, breast cancer, and GCs) via a variety of mechanisms, including mutations, overexpression of Wnt proteins, decreased expression, gene fusion, and increased tumorigenesis; these data are summarized in the boxes. Protein symbols: BCL9, B-cell CLL or lymphoma 9; BMP4, bone morphogenetic protein 4; CELSR1, cadherin EGF LAG seven-pass G-type receptor 1; FBXW7, F-box and WD Repeat Domain -containing 7; FLT3, Fms-related tyrosine kinase 3; NKD1, naked cuticle homolog 1; PEG3/Pwl, paternally expressed 3; PLAG2, pleiomorphic adenoma-like protein 2; SFRP1, secreted frizzled-related protein 1; VANGL, Vang-like protein; WIF-1, Wnt-inhibitory factor 1.