Table 2.
Prognostic factors for overall survival.
| Variable (above ULN) | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P (1) | n | HR (95% CI) | P (1) | n | ||
| Gender | Male vs. Female | 0.78 (0.6–1) | 0.06 | 240 | na | ||
| CEA | >3.5 mcg/L | 1.45 (1–1.9) | 0.02 | 206 | 1.4 (0.9–2.1) | 0.1 | 206 |
| CA19-9 | >37 U/mL | 1.2 (0.7–1.8) | 0.3 | 220 | na | ||
| CRP | >0.6 mg/dL | 1.7 (1.3–2.1) | <0.001 | 204 | 1.5 (1–2.1) | 0.026 | 204 |
| Leucocytes | >10 G/L | 1.57 (1–2.1) | <0.006 | 236 | 1.4 (0.9–2.1) | 1.1 | 236 |
| Neutrophils | >7 G/L | 1.7 (1.2–2.6) | 0.003 | 171 | 1.3 (0.7–2) | 0.8 | 171 |
| Monocytes | >1 G/L | 1.8 (1–3.2) | <0.039 | 171 | 1.2 (0.8–1.9) | 0.2 | 171 |
| NLR | >6 (ROC) | 1.7 (1.2–2.4) | <0.001 | 171 | 1.7 (1.2–2.6) | 0.003 | 171 |
| LMR | >3.98 (ROC) | 0.6 (0.4–0.8) | 0.01 | 171 | 1.4 (0.9–2.1) | 1.1 | 171 |
| Plt/LR | >333 (ROC) | 1.1 (0.7–1.7) | 0.5 | 171 | 1.6 (1.–2.6) | 0.2 | 171 |
| Platelets | >400 G/L | 1 (0.6–1.6) | 0.9 | 236 | na | ||
Abbreviations: ULN = upper limit of normal, cox regression analyses, Ci = confidence interval, na = not available, vs. = versus, NLR = neutrophils to lymphocytes ratio, LMR = lymphocytes to monocytes ratio, PLT/LR = platelets to lymphocyte ratio, G = giga, ROC = ROC Youden Analyses.