Table 3.
Concentration of growth factors and cytokines in aqueous humor (AH) according to anti-VEGF treatment response.
| Rapid-Response to anti-VEGF (n = 11) | Delayed-Response to anti-VEGF (n = 11) | Non-Response to anti-VEGF (n = 9) | p-Value | |
|---|---|---|---|---|
| Group | 1 | 2 | 3 | |
| VEGF (pg/mL) | 62.2 (10–160) | 10.1 (2.7–26.8) | 2.7 (2.7–55) | 0.08 * |
| 0.03 ** | ||||
| PIGF (pg/mL) | 266 (3.8–266) | 266 (8.9–266) | 266 (2.6–266) | 0.84 * |
| 0.99 ** | ||||
| HGF (pg/mL) | 343 (35.19–433) | 482 (198–2036) | 258 (177–759) | 0.15 * |
| 0.94 ** | ||||
| Angiopoietin-2 (pg/mL) | 5.6 (4.5–20.7) | 15.5 (5.6–30.62) | 6.8 (2–21.9) | 0.13 * |
| 0.88 ** | ||||
| PDGF-AA (pg/mL) | 18.9 (6.8–18.9) | 27.2 (22–27.3) | 13 (11.2–17.5) | 0.74 * |
| 0.37 ** | ||||
| MMP-9 (pg/mL) | 74.3 (28.4–174) | 237 (93.4–282) | 73 (2–182) | 0.07 * |
| 0.41 ** | ||||
| IL-6 (pg/mL) | 4 (0.7–17) | 6.7 (3–13.6) | 1.52 (0.7–7.7) | 0.51 * |
| 0.71 ** | ||||
| IL-8 (pg/mL) | 3.2 (1.6–10.6) | 11.5 (4.1–25.8) | 4.9 (2.3–12.4) | 0.07* |
| 0.60 ** | ||||
| TNFR1 (pg/mL) | 122 (32.5–168) | 171 (91.4–307) | 114 (46.5–219) | 0.10 * |
| 0.90 ** | ||||
| TNFR2 (pg/mL) | 215 (85.3–372) | 340 (210–755) | 234 (124–352) | 0.07 * |
| 0.76 ** |
Data are median (CI 25%–75%). *: p-value between group 1 and group 2, **: p-value between group 1 and group 3. VEGF: Vascular endothelial growth factor; PlGF: placental growth factor; HGF: hepatocyte growth factor; PDGF: platelet derived growth factor; MMP: matrix metalloproteinase; IL: interleukin; TNF: tumor necrosis factor; TNFR: tumor necrosis factor receptor.