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. 2019 Nov 8;8(11):1408. doi: 10.3390/cells8111408

Figure 6.

Figure 6

Thioalbamide inhibits metabolic functions in MCF7 cells. A Seahorse XFe96 analyzer was employed to analyze mitochondrial respiration and glycolytic function in MCF7 cells treated with thioalbamide for 48 h by monitoring oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR), respectively. (a) OCR representative tracings of MCF7 cells treated with DMSO (control) or 50–100 nM thioalbamide. (b) Histograms of mitochondrial respiration parameters. (c) ECAR representative tracings of MCF7 cells treated with DMSO (control) and 50–100 nM thioalbamide. (d) Histograms of glycolytic function parameters. Significant reductions of mitochondrial and glycolytic function were observed experimentally. Values represent the mean ± SEM of five biological replicates of three independent experiments. *** P value < 0.001; **** P value < 0.0001.