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NV556 dose-response effect on gene expression in 3D human liver model reseeded with LX2 cells. Data are represented as mean of relative expression to inactive control ± SD for LOX (A), COL1A1 (B), COL3A1 (C) and COL4A1 (D) expression and statistically analyzed by one-way ANOVA, followed by Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, and ***p < 0.001. #p <0.05 for TGF-β1 versus nontreated Control cells, n = 4 scaffolds per condition investigated.
