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. 2019 Nov 11;8(11):1417. doi: 10.3390/cells8111417

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation of infectious RSV virus production with impaired mitochondrial respiration in cell lines knocked out for specific mitochondrial genes and/or retrovirus-rescued. KO derivatives thereof lacking Complex I α subcomplex subunit 10 (FA10^−/−), FB10^−/−, or transmembrane protein 261 (TMEM261^−/−), as well as retrovirus-rescued controls (FA10*, FB10*, and TMEM261*) were (A and B) infected with RSV (MOI indicated) for 24 h prior to analysis for the cell-associated virus by (A) qPCR and (B) plaque assays to determine the viral RNA copy number and infectious virus (plaque forming units pfu/mL), respectively, or (C) assessment for their mitochondrial bioenergetic activities as per Figure 1B. Results represent the mean ± SEM (n = 3 independent experiments, each performed in triplicate). *** p < 0.001, * p < 0.05 compared to the rescued or wild-type cells.