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. 2019 Nov 11;8(11):1417. doi: 10.3390/cells8111417

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The mtROS scavenger mitoquinone mesylate (MitoQ) protects against RSV infection in human embryonic kidney cells. RSV-infected (MOI 1) wild-type or FA10^−/− HEK293T cells were treated with MitoQ (1 µM) for the times indicated, followed by cell lysate preparation, with (A) qPCR and (B) plaque assay performed to determine the viral RNA copy number and infectious virus (plaque forming units pfu/mL), respectively. Results shown represent the mean ± SEM (n = 3 independent experiments, each performed in triplicate). Two-way analysis of variance (ANOVA) analysis was performed. *** p < 0.001 compared to the vehicle-treated respective cell lines. RSV genome copies and virus production levels were also statistically significant between wild-type and FA1^−/− HEK293T cells (*** p < 0.001).