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. 2019 Nov 6;8(11):1887. doi: 10.3390/jcm8111887

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Vglut2^f/f;DAT-Cre mice show blunted behavioral response to amphetamine, as measured in a home-cage environment. (A and B) Male and female knockout mice showed a reduced behavioral response to amphetamine as shown by significantly lower total activity at all three doses of amphetamine. (C and D) Male and female knockout mice display a shift in dose-response to amphetamine-induced locomotion. (E and F) Male and female knockout mice show a different dose-response profile regarding rearing behavior in response to amphetamine. A right shift in dose-response in locomotion is apparent in the Vglut2^f/f;DAT-Cre mice. Data were analyzed with one-way ANOVA followed by Tukey’s post-hoc test when appropriate. Data are presented as mean ± SEM (n = 9). *, P < 0.05; **, P < 0.01; ***, P < 0.001. Reprinted from Birgner et al., 2010 [54].